Principal Research Interests:
- Ultrastructural changes of CD4 positive lymphocytes before and after HIV infection in culture. Internalization, processing, and extrusion of virus protein concomitantly with changes of the lymphocyte plasma membrane changes.
- Isolation of RNA messages and/or proteins that are produced in brain tissues as the result of insulting the peripheral nerves and receptors.
- Cellular/ultrastructural changes in normal and induced anomalies of inner ear sensory organs, including neuronal degeneration.
- Objective quantification via computerized video microscopy using color thresholding as a key factor in evaluation changes in hues and intensities.
- Relationships that may exist between the development of the epithelia and gelatinous membranes of the inner ear.
- Effects of microgravity and zero-gravity environment on the development of the inner ear (space station flights).
- Cytodifferentiation of the sensory epithelia of the inner ear with special interest on relation of synapse formation and morphologic refinement to onset of hearing function.
- Neuronal plasticity: Changes in peripheral and central components of the vestibular nervous system following ablation of inner ear end-organ or transection of eighth nerve branches.
Publications excluding abstracts
Choi, B., Gatti, P.J., Haislip, A.M., Fermin, C.D. and Garry, R.F. Effects of altered potassium media on HIV production. Virology, In Press, 1998.
Fermin, CD, Lychakov, D, Campos, A, Hara, H, Sondag, E, Jones, T, Jones, S, Taylor M, Meza-Ruiz, G and Martin, DS. Otoconia biogenesis, phylogeny, composition & functional attributes. Histol & Histopath In Press, 1998.
Gatti, PJ, Fermin, CD and Garry, RF. Inhibition of HIV-1 production by hygromycin B, a selectively permeable translational inhibitor. AIDS In Press, 1998.
Hara, H. Chen, X, Hartsfield, JF, Hara, J, Martin, D. and Fermin, CD Chicken (Gallus domesticus) inner ear afferents. Primary Sensory Neuron, 2(4):253-274, 1998.
Fermin, C.D. and Martin, DS. & Hirotaka Hara. Color threshold and ratio of S100ß, MAP5, NF68/200 GABA and GAD. I Distribution in inner ear afferents. Cell Vision 4(5):280-297, 1998.
Makutonina, A, Norris, CH, Plymale, DR, Gatti, PJ, Fermin, CD, Tensza, SB, Meitzner, TA, Montelaro, RC , and Garry, RF. A synthetic peptide corresponding to the carboxy terminus of human immunodificiency virus type 1 transmembrane glycoprotein induces alterations in the ionic permeability of Xenopus leavis oocytes. AIDS 13:(17): 1525-1532,1997.
Voss, TG, Fermin, CD, Levy, JA, Vigh SG, Garry, RF. Alteration of intracellular potassium and sodium concentrations corelates with induction of cytopathic effects by human immunodeficiency virus. J Virol, Submitted. 1996
Voss, TG, Gatti, PJ, Fermin, CD and Garry, RF. Reduction of human immunodeficiency virus production and cytopathic effects by inhibitors of the NA+K+CL- cotransporter. Virolory 128: 000--000, 1996 In Press.
Garry, RF Fermin, CD, Kohler, PF, Markert, ML Hong, L. Antibodies against retroviral proteins and nuclear antigens in a subset of idiopathic CD4+ T-lymphocytopenia patients. AIDS Res Human Retrov. In Press.
Zimmermann, U and Fermin, CD. Shape deformation of the organ of Corti associataed with length changes of outer hair cell. Acta Otolaryngol #1425-95, in Press.
Fermin, CD, Martin, DS, Jones, T, Vellinger, J, Deuser, M, Hester, P and Hullinger, R. Microgravity in the STS-29 Space Shuttle Discovery affected the vestibular system of chick embryos. Histol Histopath 11 (2):407-426, 1996.
Plymale, DR, Tang, DS Ng, Fermin, CD, Lewis, DE, Martin, DS and Garry, RF. Comparison of DNA Fragmentation and color thresholding for objective quantitation of apoptotic cells. Scanning Microscopy 9(3):833-842, 1995.
Fermin, CD, Lee, DH and Martin DS. Elliptical-P cells in the avian perilymphatic interface of the tegmentum vasculosum. Scanning Microscopy 9(4):1207-1222, 1995.
Mason-Garcia M, Harlan, RE, Mallia, C. Jeter, Jr. JR, Steinbers, HB, Fermin, CD, Beckman, BS. Interleukin-3 or erythropoietin induced nuclear localization of protein kinase c ß isoforms in hematopoietic targe cells. Cell Proliferation,. Ms # 158: In Press, 1995.
Fermin, CD & Steve Degraw, Color Thresholding in video imaging. Journal of Anatomy, (invited-peer reviewed) 186:469-481, 1995.
Fermin, CD, Martin, DS, Li, Y-T & Li, S-C. The glycan keratan sulfate in inner ear crystals. Cellular and Molecular Biology, 41: 577-591, 1995.
Domingue, GJ, Ghoniem, GM Bost, KL Fermin, CD, Human, LG. Dormant microbes in interstitial cystitis. Journal of Urology, 153:1321-1326, 1995.
Fermin, CD. and Martin, DS. Expression of S-100ß in sensory & secretory cells of the vertebrate inner ear. Cellular and Molecular Biology, 41:213-225,1995
Zenner, HP, Reuter, G, Zimmemann, U, Gitter, AH, Fermin C LePage, EL. Transitory endolymph leakage induced hearing loss and tinnitus: depolarization, biphasic shortening and loss of electromotility of auter hair cells. Eur. Arch. Otorhinolaryngol, 25:143-153, 1994.
Fermin, CD, Lee, DH and Martin, DE Post-embedding TEM signal to noise ratio of S-100. Hear Res,. 73(2):195-202, 1994.
Guth, P.S., Fermin, C.D., Pantoja, M., Edwards, R and Norris, C. Hair cells of different shapes and their placement along the frog crista ampullaris. Hear. Res,. 73 (1) 109-115,1994.
Jones, TA, Fermin, CD, Hester, PY and Vellinger, J: Effect of microgravity on vestibular ontogeny: Direct physiological and anatomical measurements following space flight (STS-29). Acta Vet. BRNO, 62(suppl 6), S-35-S42, 1993..
Hester, PY, Mcginnis, ME, Vellinger, JC, Deuser, MS and Fermin, CD: Avian embryogenesis in microgravity aboard shuttle STS-29: Effect on shell mineral content and post-hatch performance. Acta Vet. BRNO, 62(suppl 6), S-43-S47, 1993.
Garry, RF and Fermin, CD, Viral burden in AIDS. Nature, 365:301-302, 1993.
Fermin, C.D. High resolution & image processing of otoconial matrix. Microscopy Res. & techn 25:297-303,1993.
Fermin, CD and Garry, RF. Über die mögliche beteilingung eines kürzlich entderckten humanen retrovirus and idiopathisch immunologischen störungen einschließlich dem Sjögren-syndrom (autoimmune Exokrinopathie). HNO, 41:239-249, 1993
Guth, P., Norris, C; and Fermin, CD and M. Pantoja: The correlated blanching of synaptic bodies and reduction in afferent firing rates caused by transmitter-depleting agents in the frog semicircular canal. Hear. Res,. 66:143-149, 1993.
Fermin, CD; Garry, RF: Cytopathic effects linked to early interactions of human immunodeficiency virus with the cell surface. Virology ,191:941-946, 1992.
Yoshihara, T, Kaname, H, Narita, N, Ishii, T, Igarashi, M, Fermin, CD. Development of the endolymphatic sac in chick embryos, with reference to the degradation of otoconia. ORL, 54(5):235-240,1992.
Fermin, C.D., Gerber, M.A. and Torre-Bueno, J. Color thresholding & objective quantification in bioimaging. Journ. Microscopy , 167:(1) 85-96, 1992.
Humbert, J.R., Fermin, C.D. and Winsor, EL. Early sequential granulocyte damage. Seminar in Hematology., 28: 31-38, 1991.
Vigh S., Arimura, A., Koves, K. Somogyvari-Vigh, A. Sitton, J. and Fermin, C.D Immuno-histochemical demonstration of a novel hypothalamic neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), in human and primate hypothalamus. Peptides, 12:313-318, 1991.
Yoshihara, T., Igarashi, M. and Fermin, C.D. Ultracytochemical localization of NA+, K +-ATPase activity in the tegmentum vasculosum of the developing chick cochlea. Acta Otolaryngol,. 110: 366-373,1990.
Garry, FG, Fermin, CD, Hart, DJ, Alexander, SS and Luo-Zhang, H: Detection of a human intracisternal A-type retroviral particle that is antigenically-related to HIV. Science, 250:1157-1159, 1990.
Beckman, BS, Mason-Garcia, M., Martinez, M. and Fermin, CD: Enhanced expression of the Beta II subspecies of protein kinase C in differentiating eythroleukemia cells. Exp. Cell Res., 191: 319-322, 1990.
Fermin CD, Lovett A, Igarashi M, Dunner K: Immunohisto-chemistry and histochemistry of the inner ear gelatinous membranes and statoconia of chick (Gallus domesticus). Acta Anatomica, 138:75-83, 1990.
Fermin CD, Igarashi M, Martin G, Jenkins H: Ultrastructural evidence of repair and neuron survival after labyrinthectomy in the squirrel monkey. Acta Anatomica, 135:62-70, 1989.
Fermin CD, Igarashi M: Morphometry and ultrastructure of the squirrel monkey (Saimiri sciureus) vestibular nerve. Acta Anatomica., 129:188-199,1987.
Fermin CD, Igarashi M, Yoshihara T: Ultrastructural changes of statoconia after segmentation of the otolithic membrane. Hear Res., 28:23-34, 1987.
Yoshihara T, Fermin C, Igarashi M: Localization of Na-K-ATPase in the tegmentum vasculosum of the chick. Arch Otorhino-laryngol., 243:401-402, 1987.
Yoshihara T, Usami S, Igarashi M, Fermin CD: Ultracytochemical study of ouabain-sensitive, potassium-dependent p-nitro-phenylphosphatase activity in the inner ear of squirrel monkey. Acta Otolaryngol., 102:161-169, 1987.
Fermin CD, Igarashi M: Review of statoconia formation in birds and original research in chicks (Gallus domesticus). Scanning Microscopy, 4:1649-1665, 1986.
Fermin CD, Igarashi M: Development of statoconia in the embryonic chick (Gallus domesticus). Acta Anatomica, 123:148-152, 1985.
Cohen GM, Fermin CD: Development of the embryonic chick's tectorial membrane. Hear Res., 18:29-39, 1985.
Fermin CD, Colmers WF, Igarashi M: Electron microscopic observations of the gravity receptor epithelia of normal and spinner juvenile Octopus maya. Tissue and Cell Research, 240:702-704, 1985.
Fermin CD, Cohen GM: Development of the chick's statocoustic ganglion. Acta Otolaryngol, 98 (1-2):42-52, 1984.
Fermin CD, Igarashi M: Dendritic growth following labyrinthectomy in the squirrel monkey. Acta Otolaryngol, 97:39-51, 1984.
Fermin CD, Cohen GM: Developmental gradient along the chick's basilar papilla. Acta Otolaryngol, 97:39-51, 1984.
Otto SV, Park JC, Fermin CD, Cohen GM: A new method for improved fixation of the chick's inner ear. Florida Scientist, 47 (4):251-256, 1984.
Fermin CD, Igarashi M: Aminoglycoside ototoxicity in the chick (Gallus domesticus) inner ear. 1. The effect of kanamycin and netilmicin on the basilar papilla. Am J Otolaryngol, 4:174-183, 1983.
Fermin CD, Igarashi M: The vestibular ganglia of the squirrel monkey (Saimiri sciureus). Ann Otol Rhinol Laryngol, 91:44-52, 1982.
Clark KB, Jensen KK, Stirts HM, Fermin CD: Chloroplast symbiosis in a nonelysiid molusc, Costasiella lilianae Marcus (Hermaeidae: ascoglossa (=sacoglossa)): Effect of temperature, light intensity, and starvation on carbon fixation rate. Biol Bull, 160:43-55, 1981.
Cohen, GM, Fermin CD: The development of hair cells in the embryonic chick's basilar papilla. Acta Otolaryngol, 86:342-358, 1978.
Book Chapters
Gallaher, W., Fermin, C.D. Henderson, L., et al., Membrane interactions of HIV. Implications for pathogenesis and therapy in AIDS: Attachment, fusion, and cytopathology. In: Advances in Membrane Fluidity. Roland C. Aloia ed. Vol. 6., pages 113-142. Wiley-Liss, Inc. NY 1992.
Garry, RF, Kreig, AM, Cheevers, WP, Montelaro, RC, Golding and Fermin, CD. Retroviruses and their roles in chronic inflammatory diseases and autoimmunity. In: The Retroviridae, JA Levy Ed. Vol. 4:491-603, 1995.
Fermin, C.D. La fisiología auditiva. En: Medicina de la Comunicación Humana, Y.Peñaloza et al. eds.. Instituto Nacional de la Comunicación Humana y Subsecretaría de Servicios de Salud (SSA) Mexico. 1994. Pages 301-322.
Fermin, CD. Neurotransmisión vestibular central. I Componentes y deficiones. En: NEUROBIOLOGIA DE LOS SISTEMAS SENSORIALES. Meza-Ruiz, G. Ed. Universidad Autonoma de Mexico, Mexico. Chapter 14, pages 285-317, 1995 First edition. Mexico, DF.
Fermin, CD, D. S. Martin and T.A. Jones. Neurotransmisión vestibular central. II Función y aspectos moleculares. En: NEUROBIOLOGIA DE LOS SISTEMAS SENSORIALES . Meza-Ruiz, G. Ed. Universidad Autonoma de Mexico. Mexico, Chapter 15, pages 317-363, 1995. First edition. Mexico, DF.
Proceedings and Rapid Communications
Hara, H., Meza, G., Bohne, B., Hara, J. and Fermin, CD. Aminoglycoside damage to young rats equilibrium. In: Bailey & Garratt-Reed eds. 56th Ann meet. Micr Soc Am, In Press, 1998, San Francisco Press, Inc. CA.
Hara, H. and Fermin, CD. 2G alters the utricular macula of cheick embryos. In: Bailey & Garratt-Reed eds. 56th Ann meet. Micr Soc Am, In Press, 1998, San Francisco Press, Inc. CA
Fermin, CD. Funding mechanisms. The Scientist, 9(24):13,1995.
Fermin, CD. Anatomy, histology and color thresholding. Microscopy Today 95-5:16, 1995
Fermin, CD Neuronal proteins before, during and after vestibular synaptogenesis. NASA Techn. Memorandum 12/1994: 124-128, 1995.
Fermin, C.D. and Martin, D. Otoconia perfect/imperfect crystals. In: Bailey & Garratt-Reed eds. 52th Ann meet. Micr Soc Am, Pages 42-43, San Francisco Press, Inc. CA,1994.
Jones, TA, Vellinger, J Hester, PY, Fermin C. Weightlessness and the ontogeny of vestibular function: evidence for persistent vestibular threshold shifts in chicks incubated in space. Physiologist S34:143-144, 1991.
Fermin, C.D. Influences of synaptic genesis on the architecture of vestibular epithelia. II NASA Techn. Memorandum 4258: 106-108, 1990.
Fermin, CD; Martin, D Diaz, E; Maldonado, Hruska Z. A and Rapid processing of black and white film in the EM lab. J Elect. Microsc. Techn 16:85-86,1990.
Fermin, CD: Tritiated Thymidine in the Chick Embryo Inner Ear. 47th Annual Proceedings of the Electron Microscopy Society of America, pp. 846-847, 1989.
Fermin, C.D. Influences of synaptic genesis on the architecture of vestibular epithelia. I NASA Techn. Memo 4160: 108-110, 1989.
Fermin, CD, Zenner, H-P: Hair Cell Changes After Cationic Stimulation of Corti's Organ. 47th Annual Proceedings of the Electron Microscopy Society of America, pp. 798-799, 1989.
Fermin, CD. Otoconia Calcification Process: A Chick Embryo Model (III). NASA Technical Memorandum 4079:113-116, 1988.
Fermin, CD. Otoconia Calcification Process: A Chick Embryo Model (II). NASA Technical Memorandum 89951:124-127, 1987.
Fermin, CD. Otoconia Calcification Process: A Chick Embryo Model (I). NASA Technical Memorandum 89809:103-106, 1986.
Fermin, CD, Igarashi M: The vestibular nerve and ganglia of the squirrel monkey after labyrinthectomy. 40th Ann Proc El Micr Soc Am, 1982, p196-197.
Fermin, CD, Igarashi M: Otoconia formation in the chick embryo. 41st Ann Proc El Micr Soc Am, 1983, p 572-573.
Fermin, CD, Igarashi M: Morphological characterization of the vestibular nerve. 43rd Ann Proc El Micr Soc Am, 1985, p 590-591.
Fermin, CD, Igarashi M: Morphogenesis and calcification of the statoconia in the chick (Gallus domesticus) embryo: Implications for future studies. The Physiologist 28 (2): S87-S88, 1985.
Fermin, CD, Igarashi M: Deafferentated vestibular nerve. 41st Ann Proc El Micr Soc Am, 1983, p 652-653.
Fermin, CD, Igarashi M, Thompson G: The stapedius muscle of the squirrel monkey. 41st Ann Proc Soc Am, 1983, p 528-529.
Fermin, CD, Cohen GM: The chicken's intraaural muscle. 37th Ann Proc El Micro Soc Am, 1979, p 210-211.
Cohen, GM, Siegel AJ, Fermin CD: Procedure for contrasting glycogen in the embryonic chick's inner ear. 35th Ann Proc El Mic Soc Am, 1977, p 546-547.
